Material Safety Data Sheet (MSDS): Threonine

Identification

Product Name: Threonine
Chemical Name: L-threonine
CAS Number: 72-19-5
Synonyms: 2-Amino-3-hydroxybutyric acid
Recommended Use: Nutritional supplement, feed additive, biochemical research
Supplier Details: Reference to actual supplier or distributor information
Emergency Contact: Reference to available emergency contact number for immediate help related to spills or medical incidents

Hazard Identification

Classification: Not classified as hazardous according to GHS criteria
Physical Hazards: Dust formation may cause mechanical irritation or respiratory discomfort
Health Hazards: May cause minor eye and skin irritation on direct contact
Environmental Hazards: Expected to be low risk to aquatic life, improper disposal may contribute to localized problems
Label Elements: No symbol required, precautionary statements may advise basic hygiene and dust control
Signal Word: None applicable for this chemical
Potential Effects: Short-term exposure by ingestion or inhalation rarely produces symptoms, but repeated or excessive exposure to powder dust could irritate airways

Composition / Information on Ingredients

Chemical Name: L-threonine
Common Name: Threonine
CAS Number: 72-19-5
Percentage: 98-100% pure depending on source and grade
Impurities: May include trace amounts of other amino acids or residual solvents, generally below 1%

First Aid Measures

Inhalation: Move exposed person to fresh air and keep at rest, seek medical advice if discomfort continues
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, seek attention if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, obtain medical attention if symptoms persist
Ingestion: Rinse mouth, give water if conscious, do not induce vomiting, consult healthcare professional if large quantity ingested or abnormal symptoms appear
Acute Symptoms: May include mild respiratory tract irritation or digestive discomfort after large acute exposures

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides at high temperatures
Special Precautions: Firefighters should wear suitable protective equipment and self-contained breathing apparatus
Unusual Fire Hazards: Fine powders may pose dust explosion hazard in confined conditions, avoid stirring up dust clouds near ignition sources
Protective Actions: Move containers from fire area if safe to do so, cool containers with water spray

Accidental Release Measures

Personal Precautions: Wear appropriate personal protection to avoid dust inhalation and skin contact
Environmental Precautions: Prevent material from entering drains, surface water, or soil to avoid localized pollution
Methods for Clean-up: Sweep or vacuum spilled product and place in a suitable labeled container for recovery or disposal, minimize dust generation
Decontamination: Wash spill area with water after clean-up, ventilate confined spaces

Handling and Storage

Safe Handling: Use in well-ventilated areas, avoid creating excessive dust, prevent prolonged skin or eye contact, use mechanical handling methods to reduce airborne particles
Conditions for Storage: Store in cool, dry, well-ventilated place away from incompatible substances, keep containers tightly closed and properly labeled
Incompatibles: Strong oxidizing agents, direct sunlight, moisture may lead to quality degradation
Hygiene Practices: Keep food, drink, and animal feeding stuffs away from storage and handling area, always wash hands thoroughly after handling

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits assigned for threonine
Engineering Controls: Provide local exhaust ventilation where dust is generated, use enclosed handling systems if possible
Personal Protection: Use protective gloves (PVC, nitrile, or rubber), safety goggles or face shield, dust masks for prolonged or repeated exposure
Respiratory Protection: Approved particulate respirator recommended in case of high dust concentrations
Other Protection: Work clothing or aprons advisable for frequent handling, eye-wash stations within easy reach

Physical and Chemical Properties

Appearance: White crystalline or fine powder
Odor: Odorless
pH: 5.5 – 6.5 (1% aqueous solution)
Melting Point: 256°C (decomposes)
Solubility: Soluble in water, practically insoluble in ethanol, ether, and chloroform
Vapor Pressure: Negligible at room temperature
Boiling Point: Not applicable (decomposition occurs before boiling)
Flash Point: Not applicable
Density: ~1.5 g/cm³
Molecular Formula: C4H9NO3
Molecular Weight: 119.12 g/mol
Evaporation Rate: Not relevant for solid
Other Data: Stable under recommended conditions, forms stable aqueous solutions

Stability and Reactivity

Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Low chemical reactivity, does not undergo hazardous polymerization
Conditions to Avoid: Excessive heat, open flames, moisture, direct sunlight
Incompatible Materials: Strong oxidizers, acids, bases
Decomposition Products: Oxides of carbon and nitrogen formed on decomposition
Hazardous Reactions: No hazardous reactions expected if stored and handled properly

Toxicological Information

Acute Toxicity: Low oral toxicity, LD50 (rat) >5000 mg/kg, no significant symptoms reported in animal studies
Chronic Toxicity: No long-term effects documented for intended use amounts
Skin Irritation: May weakly irritate skin after repeated or prolonged exposure
Eye Irritation: Mild irritation possible upon direct contact
Inhalation: Dust may irritate respiratory tract, not expected to cause serious injury
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a suspected carcinogen
Mutagenicity: No evidence found in standard tests
Reproductive Effects: No effects reported in existing animal studies for nutritional doses

Ecological Information

Ecotoxicity: Not highly toxic to aquatic or terrestrial species, but large quantities may cause nutrient imbalances in sensitive ecosystems
Persistence and Degradability: Readily biodegradable, natural amino acid component, rapidly metabolized by soil and water organisms
Bioaccumulative Potential: Not expected to accumulate in living organisms
Mobility in Soil: Moderate mobility, soluble in water, may leach depending on site conditions
Other Adverse Effects: None identified at usual use and disposal levels

Disposal Considerations

Waste Treatment Methods: Small quantities can go in regular chemical waste streams if permitted by local regulations
Disposal of Contaminated Packaging: Rinse, deface, and send for recycling or disposal as required
Precautions: Do not discharge into sewers or water bodies, seek advice from local authorities for bulk or persistent waste
Recycling: If unopened and uncontaminated, surplus product may suit third-party recycling programs

Transport Information

UN Number: Not regulated
Proper Shipping Name: Not regulated for ground, air, or sea transportation
Transport Hazard Class: None assigned
Packing Group: Not applicable
Special Precautions: Avoid dust generation and container breakage, secure loads to prevent shifting during transport
Environmental Hazards: Not classified as marine pollutant

Regulatory Information

International Inventories: Listed on TSCA, EINECS/ELINCS, AICS, DSL, ENCS, and other major inventories
OSHA Hazards: No specific OSHA hazards
SARA Title III: Not subject to reporting under Sections 302, 304, 311/312, or 313
WHMIS Classification: Exempt, food additive
REACH: Not classified as hazardous, complies with requirements for food and feed use
Labelling Requirements: No special hazard labeling required under GHS for consumer or occupational use where managed as per guidance
Restrictions: Use governed by feed, food, and chemical safety regulations relevant to location