Material Safety Data Sheet for Proline

Identification

Product Name: Proline
Chemical Name: L-Proline
Synonyms: Pyrrolidine-2-carboxylic acid
Chemical Formula: C5H9NO2
Molecular Weight: 115.13 g/mol
CAS Number: 147-85-3
Recommended Use: Laboratory chemicals, industrial applications, and research
Supplier Information: Supplier name, street address, city, state, ZIP code, and emergency telephone number found on shipment label

Hazard Identification

GHS Classification: Not classified as hazardous under GHS
Signal Word: None
Hazard Statements: Not expected to have hazardous effects under normal use
Precautionary Statements: Avoid inhalation, limit dust exposure, wash hands after handling
Physical Hazards: Dust may cause mild irritation
Health Hazards: May cause eye or respiratory irritation if handled improperly
Environmental Hazards: Not considered an environmental hazard

Composition / Information on Ingredients

Chemical Name: L-Proline
Chemical Formula: C5H9NO2
Concentration: 98%–100%
Impurities: Minor organic or inorganic trace impurities may be present in amounts less than 2%
Additives: None

First Aid Measures

Inhalation: Move to fresh air and rest. Seek medical attention if symptoms develop
Skin Contact: Wash exposed skin thoroughly with soap and water
Eye Contact: Rinse eyes cautiously with water for several minutes. Remove contact lenses if present and continue rinsing. Seek medical attention if irritation persists
Ingestion: Rinse mouth with water, seek medical advice if large amounts are swallowed or symptoms arise

Fire-Fighting Measures

Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam extinguishers
Unsuitable Extinguishing Media: No information indicating unsuitable choices for this material
Specific Hazards: During fire, potential evolution of carbon monoxide, carbon dioxide, or nitrogen oxides
Special Protective Equipment: Firefighters need appropriate self-contained breathing apparatus and complete protective clothing
Advice for Firefighters: Avoid inhaling combustion gases, cool exposed containers with water spray to control temperatures

Accidental Release Measures

Personal Precautions: Avoid breathing dust, use adequate ventilation, wear protective gear
Environmental Precautions: Contain spill to prevent spreading to water systems
Methods for Cleanup: Sweep up gently to avoid dust, place material in suitable waste container for disposal, wash affected area with water after collection

Handling and Storage

Precautions for Safe Handling: Use in a well-ventilated space, prevent dust formation, wash hands before eating or drinking
Safe Storage Conditions: Store tightly sealed in cool, dry location, away from incompatible materials
Recommended Storage Temperature: 2-8°C for best shelf life
Incompatibilities: Strong oxidizers and strong acids

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits set for proline
Engineering Controls: Use good laboratory and industrial hygiene practices, provide local exhaust if dusting expected
Personal Protective Equipment: Wear safety glasses or goggles, gloves, and lab coat; offer dust mask or respirator in poorly ventilated areas
Hygiene Measures: Wash hands after use, keep work clothes separate from other clothing

Physical and Chemical Properties

Appearance: White crystalline or powder
Odor: Odorless or faintly sweet
Melting Point: 220–225°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in water
pH (solution): 5.8–7.0 (50 g/L, H2O, 20°C)
Vapor Pressure: Not applicable
Density: 1.35–1.40 g/cm³ at 20°C
Flash Point: Not flammable
Partition Coefficient (log Kow): −2.54 (measured or estimated)
Autoignition Temperature: No data available

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Conditions to Avoid: High temperatures, contact with incompatible materials
Decomposition Products: Emits carbon oxides and nitrogen oxides on combustion

Toxicological Information

Acute Toxicity (oral, rat): LD50 > 5,000 mg/kg (low toxicity)
Skin Corrosion/Irritation: Not expected to cause skin irritation
Serious Eye Damage/Irritation: May cause mild discomfort
Respiratory Sensitization: No known effects
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: No known genetic risks
Reproductive Effects: Not documented in available research
Other Information: Handle with sensible precautions to prevent excessive dust inhalation or accidental contact

Ecological Information

Ecotoxicity: No significant hazards in aquatic or terrestrial environments
Persistence and Degradability: Biodegradable, predicted to break down in environment
Bioaccumulative Potential: Not likely to bioaccumulate due to high water solubility and low log Kow
Mobility in Soil: High solubility suggests good mobility
Other Adverse Effects: No observed significant impact in standard tests

Disposal Considerations

Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations
Product Waste: Use approved chemical waste facility; avoid discharge into environment
Contaminated Packaging: Rinse and recycle or dispose of safely, follow official guidance for chemical containers

Transport Information

UN Number: Not regulated
UN Proper Shipping Name: Not regulated as dangerous goods
Transport Hazards Class: No hazard class
Packing Group: None
Environmental Hazards: Not a marine pollutant
Special Precautions: No special precautions, standard packaging

Regulatory Information

TSCA Listing: Listed in the US Toxic Substances Control Act inventory
DSL/NDSL (Canada): Listed
REACH Registration: Exempt or registered, submission available on request
SARA Title III: Not subject to reporting
California Proposition 65: Not listed
Other International Regulations: Confirm compliance according to country of use regulations
GHS Label Elements: Not required