Material Safety Data Sheet for Lysine Hydrochloride

Identification

Product Name: Lysine Hydrochloride
Chemical Formula: C6H14N2O2•HCl
Chemical Family: Amino Acid, Monohydrochloride Salt
Trade Names: Lysine HCl, L-Lysine Monohydrochloride
Synonyms: L-2,6-Diaminohexanoic acid hydrochloride, Lysine HCl
CAS Number: 657-27-2
EC Number: 211-519-9
Intended Use: Animal feed supplement, food additive, pharmaceutical intermediate
Supplier Identification: Manufacturer or distributor contact details printed on packaging

Hazard Identification

GHS Classification: Not classified as dangerous according to current regulations
Physical Hazards: May cause mild irritation to eyes and skin
Health Hazards: Dust may irritate respiratory system if inhaled, especially for workers handling powder form
Environmental Hazards: Not known to present specific risks to terrestrial or aquatic environments at normal concentrations
Signal Word: None
Pictogram: No GHS symbol required
Precautionary Statements: Avoid inhaling powder, avoid contact with eyes, ensure good ventilation during handling
Other Hazards: Slippery when spilled, risk of dust explosion in rare cases of heavy airborne dust accumulation in enclosed locations

Composition / Information on Ingredients

Chemical Name: L-Lysine Monohydrochloride
Purity: At least 98.5% (by dry material content)
Impurities: Residual moisture typically under 1.5%, trace by-products not expected to impact safety
Hazardous Components: None present at levels requiring disclosure under current standards
Other Ingredients: None added intentionally
Molecular Weight: 182.65 g/mol

First Aid Measures

Inhalation: Move affected person to fresh air; seek medical advice if symptoms persist (such as coughing, shortness of breath)
Skin Contact: Wash off with plenty of water and soap; remove contaminated clothing
Eye Contact: Rinse carefully with water for several minutes, remove contact lenses if present and easy to do; medical attention if irritation continues
Ingestion: Rinse mouth out; drink water to dilute; do not induce vomiting; seek medical advice if large quantity has been ingested or symptoms occur
Most Important Symptoms: Irritation of the eyes, skin, respiratory tract (dust)
Special Notes for Doctors: Treat symptomatically; no antidote known for this compound in normal exposures

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry powder, foam, carbon dioxide
Unsuitable Media: None known
Special Hazards: Organic dust may form explosive mixtures with air in confined areas; product decomposes on strong heating, releasing toxic gases such as oxides of nitrogen and hydrogen chloride
Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus recommended
Other Advice: Move non-emergency personnel out of area; cool exposed containers with water spray if safe
Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride gas

Accidental Release Measures

Personal Precautions: Avoid inhaling dust; use appropriate personal protective equipment, especially dust mask, safety glasses, gloves
Environmental Precautions: Keep powder out of surface water drains and soil in large spills
Spill Containment and Cleanup: Sweep up spills gently to avoid raising dust; use industrial vacuum cleaner or wet sweeping; store waste for disposal in suitable containers
Methods for Disposal: See disposal considerations section
Other Precautions: Ensure good ventilation at spill site; avoid actions that scatter powder

Handling and Storage

Precautions for Safe Handling: Avoid dust generation; ensure adequate ventilation or wear suitable masks in powder handling areas; wear protection for hands, eyes, and skin; wash hands after use
Conditions for Safe Storage: Store in tightly closed containers in cool, dry, well-ventilated locations away from direct sunlight, moisture, acids, and oxidizers
Storage Temperature: Room temperature recommended
Storage Life: Stable for at least two years under recommended storage conditions
Incompatible Materials: Strong acids, strong oxidizing agents, moisture
Other Handling Advice: Use mechanical handling aids for large containers to avoid lifting injuries

Exposure Controls and Personal Protection

Exposure Limits: No workplace exposure limits specifically assigned for Lysine HCl; general dust limit applies (ACGIH TLV Total Dust: 10 mg/m³)
Engineering Controls: Local exhaust ventilation or general room ventilation
Respiratory Protection: Dust mask or respirator if dust formation likely (especially in feed manufacturing facilities)
Eye Protection: Safety glasses with side-shields
Skin Protection: Chemical-resistant gloves, protective workwear
Hygiene Measures: Wash thoroughly after handling; no eating or drinking in handling areas
Environmental Exposure Control: Limit discharge of large amounts to prevent local nutrient contamination

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless or slight characteristic odor
pH: 5.0–6.0 (10% aqueous solution at 20°C)
Melting Point: Decomposes before melting above 260°C
Solubility: Freely soluble in water
Boiling Point: Not applicable (decomposes on heating)
Vapor Pressure: Negligible
Partition Coefficient (log Pow): -3.0 to -4.0 (calculated, very water soluble)
Bulk Density: 400–700 kg/m³ (depending on granulation)
Flash Point: Not applicable
Flammability: Non-flammable under normal conditions
Explosive Properties: Product dust may form explosive mixture with air in rare high concentration dust clouds
Auto-Ignition Temperature: Not determined

Stability and Reactivity

Chemical Stability: Stable under usual temperature and storage conditions
Reactivity: No dangerous reactivity under normal handling; reacts with strong oxidants
Conditions to Avoid: Excessive heat, formation of airborne dust clouds, contact with strong acids or bases
Materials to Avoid: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: At decomposition temperature, releases carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride
Polymerization: Will not occur

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral (rat) LD50 > 5,000 mg/kg, indicating low acute toxicity
Chronic Toxicity: No data indicating chronic effects at occupational exposure levels
Skin Irritation: Not expected to cause skin irritation.
Eye Irritation: May cause mild temporary irritation
Sensitization: Not known to cause allergic skin reaction
Mutagenicity: Tests show no evidence for genetic damage
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No evidence of reproductive effects in animal studies

Ecological Information

Ecotoxicity: Aquatic and terrestrial toxicity rated low; LC50 (fish) > 100 mg/L, EC50 (algae) > 100 mg/L
Persistence and Degradability: Readily biodegradable through metabolic breakdown by microbes
Bioaccumulation Potential: Log Pow indicates no tendency to accumulate in the environment
Mobility in Soil: Expected to be highly mobile in moist soils due to high water solubility
Other Adverse Effects: Large spills may contribute to eutrophication in sensitive waterways by providing excess nutrients

Disposal Considerations

Waste Disposal Methods: Dispose of in accordance with local, national, and regional regulations; product can usually be landfilled as non-hazardous waste
Packaging Disposal: Rinse empty containers if possible and recycle or dispose of according to local requirements
Special Instructions: Do not release large quantities into waterways
Waste Codes: Not regulated as hazardous waste under RCRA or similar regulations

Transport Information

UN Number: Not regulated
UN Proper Shipping Name: Not classified as dangerous for transport
Transport Hazard Class: Not listed
Packing Group: Not applicable
Environmental Hazards: Not classified as environmentally hazardous substance for transport purposes
Special Precautions for Transport: Keep containers tightly closed and dry; avoid packaging damage during handling

Regulatory Information

U.S. Regulations: Listed in TSCA inventory; not regulated as hazardous under SARA Title III
EU Regulations: Registered under REACH; not listed as a hazardous substance in Annex VI of CLP
Other International Lists: Listed in inventories of Canada (DSL), Australia (AICS), Japan, China, Korea
Label Requirements: Not classified as hazardous; general product labeling for feed or food ingredient applies
Other Requirements: Compliance with workplace safety standards; food/feed grade material must meet relevant national purity and hygiene standards