Material Safety Data Sheet: Isoleucine

Identification

Product Name: Isoleucine
Chemical Name: 2-Amino-3-methylpentanoic acid
Synonyms: L-Isoleucine, (S)-2-Amino-3-methylpentanoic acid
CAS Number: 73-32-5
Molecular Formula: C6H13NO2
Molecular Weight: 131.17 g/mol
Intended Use: Research, pharmaceutical formulation, food additive, dietary supplement
Supplier Information: Company addresses and emergency phone numbers are usually printed directly on the container label
Emergency Contact: Specific information from safety data sources or poison control centers

Hazard Identification

Hazard Classification: This substance is not classified as hazardous under GHS criteria
Hazard Statements: May cause minor irritation to eyes, skin, or respiratory tract on excessive exposure
Precautionary Statements: Avoid creating dust. Maintain good industrial hygiene. Avoid unnecessary contact
Signal Word: Not applicable
Pictograms: Not required
Other Hazards: Spilled powder can be slippery, inhalation of dust may cause irritation
Routes of Exposure: Skin, eyes, inhalation, ingestion

Composition / Information on Ingredients

Substance: Isoleucine
Content: >98% by weight
Impurities or Additives: Trace moisture or manufacturing by-products may exist in negligible quantities
Ingredient Information: Not mixed with other hazardous substances in standard lab or supplement grades

First Aid Measures

Inhalation: Move affected individual to fresh air. Support breathing if necessary. Seek medical attention if symptoms persist
Skin Contact: Wash area thoroughly with soap and water. Remove contaminated clothing. Seek medical help if irritation develops
Eye Contact: Rinse immediately with plenty of water. Lift eyelids and ensure thorough flushing. Contact physician for persistent discomfort
Ingestion: Rinse mouth with water. Provide water to drink. Never give anything by mouth to an unconscious person. Seek medical attention for large ingestions or persistent symptoms

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Unsuitable Extinguishing Media: Direct water jet may scatter powder
Special Hazards: Combustion produces carbon monoxide, carbon dioxide, nitrogen oxides
Firefighting Protective Equipment: Wear full protective gear, including self-contained breathing apparatus
Explosion Hazard: Fine dust can form explosive mixtures with air if enough powder is dispersed in a confined space
Advice for Firefighters: Cool containers with water from a safe distance. Isolate hazard area. Evacuate unnecessary personnel

Accidental Release Measures

Personal Precautions: Avoid generating dust. Wear appropriate personal protective equipment
Environmental Precautions: Prevent spills from entering drains, surface and groundwater
Containment Methods: Sweep or vacuum bulk material carefully. Do not use dry brushing if airborne dust risk exists
Cleanup Procedures: Place in suitable, labeled containers for recovery or disposal. Ventilate affected area. Wash spill site after removal of material
Disposal: Follow local regulations for waste disposal

Handling and Storage

Handling: Use with adequate ventilation. Avoid inhaling dust or contact with eyes, skin, or clothing. Wear protective equipment as required
Hygiene Measures: Wash thoroughly after handling and before eating, drinking, or smoking
Storage Conditions: Store in well-closed containers. Keep in a cool, dry, ventilated location. Protect from light, heat, and moisture
Compatible Materials: Usually stable in standard lab plastics and glass. Separate from strong oxidizers
Storage Life: Stable under recommended conditions. Check expiration date of commercial or laboratory materials

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established for Isoleucine by OSHA, ACGIH, NIOSH
Engineering Controls: Use local exhaust or general ventilation to minimize dust generation
Eye Protection: Safety glasses with side shields or chemical splash goggles
Skin Protection: Laboratory coats and chemical-resistant gloves
Respiratory Protection: Use NIOSH-approved dust mask if dust levels exceed recommended limits
Other Protective Measures: Emergency eyewash and shower near work area recommended

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH (solution): Approximately 5.5 – 7.0 (1% solution)
Melting Point: 284 °C (decomposes)
Boiling Point: Not applicable (decomposes)
Flash Point: Not determined
Evaporation Rate: Not volatile
Flammability: Not highly flammable but combustible as an organic solid
Explosive Properties: Fine powder may become explosive with enough air
Vapor Pressure: Negligible at room temperature
Solubility: Moderate in water
Partition Coefficient (Log Kow): -1.72 (estimated)
Auto-ignition Temperature: Not available
Decomposition Temperature: Above 284 °C
Viscosity: Not applicable
Relative Density: About 1.3 g/cm³
Molecular Structure: Chiral amino acid, branched side chain

Stability and Reactivity

Chemical Stability: Stable under normal conditions of use and storage
Reactivity: Not reactive under regular use
Hazardous Reactions: None expected
Compatible Materials: Stable with most materials including glass, plastic, and standard lab metals
Conditions to Avoid: Contact with strong acids, alkalis, oxidizers, excessive heat and moisture
Hazardous Decomposition Products: Burning yields carbon oxides, nitrogen oxides, other hazardous gases
Polymerization: Not anticipated

Toxicological Information

Acute Toxicity: Data shows extremely low toxicity. Oral LD50 for rats > 5000 mg/kg
Skin Corrosion/Irritation: May cause temporary mild irritation. Not considered corrosive
Eye Irritation: Dust may cause redness, irritation, or watering
Respiratory Irritation: Excessive inhalation of dust can cause coughing or minor throat discomfort
Sensitization: Not classified as a sensitizer
Repeated Dose Toxicity: No significant data for chronic effects at unexaggerated exposure
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No evidence from studies of these hazards
Medical Conditions Aggravated: Pre-existing respiratory issues from excessive dust exposure

Ecological Information

Aquatic Toxicity: Low expected hazard due to natural occurrence and rapid biodegradation
Persistence and Degradability: Decomposes quickly under normal microbial action
Bioaccumulative Potential: Not expected to accumulate in aquatic organisms
Mobility in Soil: Soluble in water, low volatility
Other Adverse Effects: No significant ecological risks reported at release quantities typical for research or supplement industries

Disposal Considerations

Waste Treatment: Material can usually be disposed of as non-hazardous waste in accordance with local, regional, and national regulations
Methods of Disposal: Incineration or landfill for bulk residue. Avoid dispersing into environment
Packaging Disposal: Rinse containers before recycling or disposal. Follow local reclamation guidelines
Precautions for Disposal: Avoid contact with skin, clothing, or inhalation of dust during waste handling

Transport Information

UN Number: Not regulated as a hazardous material
UN Proper Shipping Name: Not regulated
Transport Hazard Class: No classification
Packing Group: Not defined for this substance
Environmental Hazards: Not regulated
Special Precautions: Protect from moisture and excess heat during shipping. Secure containers for safe transport

Regulatory Information

OSHA: Not regulated as a specific hazardous chemical
TSCA: Listed in the United States TSCA inventory
REACH Status: Exempted or registered in European regulatory systems
SARA Title III: Not listed as a chemical hazard under emergency planning or community right-to-know
California Proposition 65: This product contains no listed substances known to the State of California to cause cancer, birth defects, or other reproductive harm
Other Regulations: No significant regulatory restrictions worldwide for pure substance in food or research grade