Material Safety Data Sheet (MSDS) – Inosine

Identification

Product Name: Inosine
Chemical Name: 9-β-D-Ribofuranosylhypoxanthine
SYNONYMS: Hypoxanthine riboside
CAS Number: 58-63-9
EC Number: 200-400-6
Recommended Use: Research and laboratory reagent, pharmaceutical intermediate
Supplier Details: Manufacturer and distributor details on request; customer service contact and emergency phone number available on SDS or request.

Hazard Identification

Classification (GHS): Inosine carries minimal hazard risk in laboratory settings, not classified as hazardous according to OSHA Hazard Communication Standard (29 CFR 1910.1200)
Hazard Statements: Not considered hazardous under normal conditions; dust or fine particles could cause mild irritation to eyes and respiratory tract
Pictogram(s): None required
Signal Word: None
Precautionary Statements: Prevent contact with eyes or prolonged inhalation of dust; keep containers closed and avoid generating dust; handle following good chemical hygiene protocols
Other Hazards: No significant risk of acute toxicity; potential to cause eye and skin dryness upon repeated contact.

Composition / Information on Ingredients

Chemical Name: Inosine
Molecular Formula: C10H12N4O5
Concentration: ≥99% pure chemical
Impurities and Stabilizing Additives: No significant impurities affecting classification
Ingredient Disclosure: Single ingredient product; no hazardous impurities present.

First Aid Measures

Eye Contact: Wash eyes with plenty of clean water for at least 15 minutes; gently lift eyelids and rinse thoroughly; seek medical advice if irritation occurs.
Skin Contact: Remove contaminated clothing; wash affected skin area with soap and water; seek medical attention if irritation persists.
Inhalation: Remove to fresh air; let person rest; seek medical attention if breathing difficulty occurs; avoid breathing dust in future use.
Ingestion: Rinse mouth with water; do not induce vomiting; give water to drink only if person is conscious and alert; medical attention needed if feeling unwell.
Notes for Medical Personnel: Treat symptomatically; no specific antidote known for inosine exposure.

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, CO₂, or foam for small fires
Specific Hazards Arising from the Chemical: Combustion can form nitrogen oxides, carbon monoxide; dust in air may create mild explosion risk, rare in normal environments
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear to prevent exposure to fumes
Special Firefighting Procedures: Move containers from fire area if safe; avoid breathing fumes or dust from combustion; cool containers with water spray.

Accidental Release Measures

Personal Precautions: Use personal protective equipment to avoid skin and eye contact; ventilate area with fresh air
Environmental Precautions: Avoid discharge to drains, surface water, and soil
Methods for Clean-up: Sweep up material without raising dust; place in suitable container for disposal; wash spill site after material pick-up
Additional Advice: Dispose of contaminated materials following local regulations.

Handling and Storage

Handling: Use in well-ventilated areas; avoid creation and inhalation of dust; wash hands and face after handling; avoid eating, drinking, or smoking in areas where material is handled
Storage: Store in tightly closed container in a dry, cool, and well-ventilated area; keep away from heat, sources of ignition, and incompatible materials; label container clearly
Storage Temperature: Recommended ambient temperature away from direct sunlight; limit moisture contact
Incompatible Materials: Strong oxidizers and acids.

Exposure Controls and Personal Protection

Control Parameters: No established OSHA or ACGIH exposure limits for inosine
Engineering Controls: Use general or local exhaust ventilation to maintain airborne levels below exposure guidelines
Personal Protective Equipment: Wear chemical-resistant gloves, safety goggles, laboratory coat or apron; use dust mask if airborne particle levels are elevated
Hygiene Measures: Wash thoroughly after handling; remove and wash contaminated clothing before reuse; do not store food in working area.

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Almost odorless
Odor Threshold: Not available
pH (1% solution): 4.0 – 6.0
Melting Point/Range: 219 – 221°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not available
Evaporation Rate: Not applicable
Flammability: Not considered flammable under standard conditions
Solubility in Water: 2.4 g/L at 20°C
Partition Coefficient (Log Pow): Not available
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: Approximately 2.06 (water = 1)
Auto-Ignition Temperature: Not available
Decomposition Temperature: No data
Viscosity: Not applicable
Explosive Properties: Dust may form explosive mixture in air, though considered a low risk.
Oxidizing Properties: Non-oxidizing.

Stability and Reactivity

Chemical Stability: Stable under normal conditions of storage and handling
Reactivity: No dangerous reactions known under proper use
Conditions to Avoid: Excessive heat, open flames, sources of ignition, moisture
Incompatible Substances: Strong oxidizers, strong acids
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides if combusted
Polymerization: Will not occur.

Toxicological Information

Acute Toxicity: Animal studies report low toxicity; LD50 (oral, rat) > 10,000 mg/kg
Skin Corrosion/Irritation: No irritation expected from normal handling
Serious Eye Damage/Irritation: May cause mild temporary irritation
Respiratory or Skin Sensitization: Not considered a sensitizer
Germ Cell Mutagenicity: Not classified as mutagenic by available data
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No adverse effects reported
Specific Target Organ Toxicity (STOT): No concerns for single or repeated exposure
Aspiration Hazard: No adverse effects suspected
Chronic Effects: Chronic exposure unlikely to cause serious effects if used according to instructions.

Ecological Information

Ecotoxicity: Not expected to be toxic to aquatic life or terrestrial organisms; no measurable persistence or bioaccumulation potential
Persistence and Degradability: Biodegradable in soil and water; breaks down rapidly via standard microbial processes
Bioaccumulative Potential: Unlikely to bioaccumulate
Mobility in Soil: Moderate due to high water solubility; not likely to persist
Other Adverse Effects: No known significant effects; avoid discharge in large quantities to watercourses as a precaution.

Disposal Considerations

Safe Handling of Waste: Observe all federal, state, and local environmental regulations for disposal
Disposal Methods: Material can be incinerated or disposed as non-hazardous chemical waste in approved landfill after consultation with authorities
Contaminated Packaging: Triple rinse or clean containers before reusing or discarding; dispose of packaging appropriately
Additional Notes: Do not allow significant quantities to enter drains or natural waterways.

Transport Information

UN Number: Not regulated
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: None
Packing Group: None
Marine Pollutant: No
Special Precautions for Transport: Protect from physical damage and moisture during transport.

Regulatory Information

OSHA Status: Not hazardous under OSHA Hazard Communication Standard
TSCA Status: Listed on TSCA inventory
SARA Title III Sections 302/304/311/312/313: Not listed as hazardous
California Proposition 65: Not listed
REACH Status: Exempted as naturally occurring substance used in research or medicinal product
Labeling: Not required for hazardous chemical labeling based on GHS criteria
Other Domestic and International Regulations: No restrictions on use or import in the United States or European Union; handle using standard laboratory chemical safety procedures.