Material Safety Data Sheet of Guanosine

Identification

Product Name: Guanosine
Chemical Formula: C10H13N5O5
CAS Number: 118-00-3
Synonyms: 9-β-D-Ribofuranosylguanine
Recommended Use: Laboratory reagent, nucleoside research, biochemistry
Manufacturer: Refer to supplier or distributor’s contact on package
Emergency Contact: Refer to local emergency telephone information
EC Number: 204-233-7

Hazard Identification

GHS Classification: Not classified as hazardous according to current regulations
Main Health Hazards: Eye, skin, or respiratory irritation with prolonged or repeated exposure
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Signal Word: None required
Hazard Statements: None expected under normal use
Precautionary Statements: Avoid dust formation, avoid inhalation, avoid contact with skin and eyes
Pictogram: No symbol required under GHS

Composition / Information on Ingredients

Chemical Name: Guanosine
Purity: ≥98%
Component: Guanosine
Concentration: 100%
Impurities/Additives: Not relevant at typical purities

First Aid Measures

Inhalation: Move victim to fresh air, get medical attention for persistent symptoms, monitor for breathing difficulty
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek care if irritation develops or persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if possible, keep washing, obtain medical aid if irritation remains
Ingestion: Rinse mouth with water, get medical advice if feeling unwell or symptoms develop

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, alcohol foam
Hazardous Combustion Products: Nitrogen oxides, carbon oxides, may produce hydrocyanic acid fumes and other toxic gases
Protective Equipment: Firefighters require self-contained breathing apparatus and protective gear
Specific Hazards: Burning may cause irritating or toxic fumes, keep containers cool with water spray
Explosion Data: Not known to be explosive or present unusual hazard

Accidental Release Measures

Personal Precautions: Use suitable personal protection (gloves, eye protection, dust mask), provide ventilation
Spill Cleanup: Sweep up dry material carefully, avoid dust, place in suitable waste container, clean area with water
Environmental Precautions: Prevent runoff into drains, ditches, or waterways, inform authorities if large spills contaminate environment
Methods for Containment: Gather up spilled product for disposal, minimize airborne dust generation

Handling and Storage

Handling: Handle in a well-ventilated space, minimize dust, avoid contact with skin, eyes, or clothing, wash hands and face after use
Storage Condition: Store at 2–8°C, keep container tightly closed, protect from light, keep dry
Incompatible Materials: Strong oxidizing agents
Other Notes: Store away from food, feed, and direct sunlight

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limits have been established
Engineering Controls: Use local exhaust or general room ventilation
Personal Protective Equipment: Safety glasses with side shields or goggles, laboratory gloves (nitrile, latex), lab coat
Respiratory Protection: Use appropriate mask if ventilation is inadequate or dust is created
Hygiene Measures: Avoid eating, drinking, or smoking when using, wash thoroughly before breaks and at end of work

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 236–237°C (decomposition)
Boiling Point: Not applicable
Solubility: Soluble in water (10 mg/mL at 25°C), insoluble in ethanol
pH: Neutral in aqueous solution
Molecular Weight: 283.24 g/mol
Vapor Pressure: Not available
Density: Approx. 1.9 g/cm³
Flash Point: Not applicable
Auto-ignition Temperature: Not determined

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not reactive with common materials under normal use
Conditions to Avoid: High temperatures, moisture, light
Materials to Avoid: Strong oxidizing agents
Hazardous Decomposition: Nitrogen oxides, carbon monoxide, carbon dioxide, possible hydrogen cyanide under incomplete combustion

Toxicological Information

Acute Toxicity: Not classified as acutely toxic based on available data
Skin Contact: Slight irritation in some cases following prolonged contact
Eye Contact: Can cause mild irritation if exposed directly
Inhalation: Dust may irritate respiratory tract
Ingestion: Generally low toxicity; large doses may cause discomfort
Chronic Effects: No effects identified in standard literature; lacks carcinogenic, mutagenic, or teratogenic effects
Sensitization: No evidence of skin sensitization

Ecological Information

Ecotoxicity: No adverse effects predicted for aquatic or terrestrial organisms at normal concentrations
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulative Potential: Unlikely based on physicochemical properties
Mobility in Soil: Expected to leach, but poses low risk
Other Adverse Effects: No known significant effects

Disposal Considerations

Disposal Methods: Dispose of in compliance with local, regional, or national regulations
Contaminated Packaging: Rinse and recycle or dispose according to regulations
Waste Codes: Not assigned specific codes, consider as non-hazardous laboratory waste

Transport Information

UN Number: Not regulated as dangerous goods
UN Proper Shipping Name: Not classified
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazard: Not considered hazardous to the environment for transportation
Special Precautions: Avoid formation of dust during loading and unloading

Regulatory Information

Safety, Health and Environmental Regulations: Not specifically regulated under most chemical safety laws
GHS Label Elements: No pictograms, hazard statements, or signal words assigned
Inventory Status: Listed on REACH, TSCA, DSL, and other major inventories
Other International Regulations: No restrictions under transport or workplace legislation
Consumer Use:** For professional or laboratory use only, not for direct human or animal consumption