Material Safety Data Sheet (MSDS) – Glutamine

Identification

Product Name: L-Glutamine
Chemical Formula: C5H10N2O3
Synonyms: 2-Amino-4-carbamoylbutyric acid, L-Gln
CAS Number: 56-85-9
Recommended Use: Nutritional supplement, laboratory reagent
Manufacturer: Contact local supplier for exact details
Emergency Phone: Refer to local regulatory and safety authority

Hazard Identification

GHS Classification: Not classified as hazardous under GHS
Health Hazards: Low toxicity, dust may irritate eyes, skin, or respiratory tract
Environmental Hazards: No significant risk to environment at common handling quantities
Signal Word: None
Pictograms: None required
Precautionary Statements: Avoid breathing dust, wash hands after use, maintain good laboratory hygiene
Potential Acute Effects: May cause mild irritation to the eyes and skin on direct contact
Potential Chronic Effects: Prolonged inhalation exposure could cause respiratory discomfort

Composition / Information on Ingredients

Chemical Name: L-Glutamine
Synonyms: 2-Amino-4-carbamoylbutyric acid, L-Gln
CAS Number: 56-85-9
Percent: ≥ 99% pure
Impurities: May contain trace moisture or residual solvents depending on manufacturing origin
Molecular Weight: 146.15 g/mol

First Aid Measures

Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present
Skin Contact: Wash with plenty of soap and water, seek medical attention if irritation develops
Inhalation: Move to fresh air, seek medical help if breathing becomes difficult or symptoms persist
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, seek medical advice in case of persistent symptoms
Important Symptoms: Mild irritation of respiratory tract, skin, or eyes
Medical Attention: Usually not required, persistent symptoms should be evaluated by healthcare professional

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam
Specific Hazards: Emits toxic fumes under fire conditions including nitrogen oxides and carbon oxides
Special Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective clothing
Fire/Explosion Risks: Powder can form combustible dust-air mixtures, avoid dust accumulation
Advice for Firefighters: Move containers from fire area if safe, cool containers with water spray

Accidental Release Measures

Personal Precautions: Avoid inhalation and contact with skin or eyes, ventilate area
Protective Equipment: Use dust mask, safety glasses, gloves
Environmental Precautions: Prevent runoff to sewers or waterways, minimize spread of dust
Methods for Clean-up: Sweep up carefully and place in suitable waste container, avoid creating airborne dust, clean spill area with soap and water
Emergency Procedures: Notify responsible personnel, evacuate unnecessary personnel from area

Handling and Storage

Safe Handling: Minimize dust generation, practice good hygiene, avoid eating, drinking, or smoking during use, use appropriate exhaust ventilation
Storage Conditions: Store in tightly closed container, keep in cool, dry, well-ventilated area
Incompatibilities: Strong oxidizing agents
Storage Temperature: Room temperature or refrigerator as recommended by supplier
Other Precautions: Keep container upright and clearly labeled, protect from physical damage and moisture

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established limit values for L-Glutamine
Engineering Controls: Local exhaust ventilation, eye wash station
Eye/Face Protection: Safety glasses with side shields
Skin Protection: Chemical-resistant gloves, laboratory coat
Respiratory Protection: Dust mask or respirator if significant dust generation occurs
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing, do not eat or drink in work area

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH (solution): Approximately 5.0–6.0 (1% solution in water)
Melting Point: >185°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility in Water: Freely soluble
Specific Gravity: 1.46
Vapor Pressure: Not applicable
Partition Coefficient (Log Kow): -3.1
Flash Point: Not flammable
Auto-Ignition Temperature: Not self-heating
Evaporation Rate: Not applicable
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures
Reactivity: Non-reactive under recommended handling
Decomposition Products: Nitrogen oxides, carbon oxides on thermal decomposition
Conditions to Avoid: Excess heat, incompatible substances, moisture
Incompatible Materials: Strong oxidizers, strong acids
Hazardous Reactions: None expected under normal conditions

Toxicological Information

Acute Toxicity: Oral LD50 (rat) >8,000 mg/kg, low acute toxicity
Irritation: Mild irritant to eyes and skin if contacted directly
Corrosivity: Non-corrosive to skin and mucous membranes
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity: Not mutagenic as per available data
Reproductive Toxicity: Not known to have reproductive effects
Sensitization: Not expected to cause allergic reaction
Chronic Effects: No evidence of long-term health effects in recommended use

Ecological Information

Ecotoxicity: Not considered hazardous to aquatic life
Persistence and Degradability: Rapidly biodegradable in environment
Bioaccumulation Potential: Does not bioaccumulate
Mobility in Soil: High mobility, dissolves in surface and groundwater
Other Adverse Effects: No further known adverse ecological effects

Disposal Considerations

Waste Treatment Methods: Dispose of in accordance with local, state, and national regulations
Product Disposal: Can be disposed with routine waste if local guidelines permit
Contaminated Packaging: Dispose of as unused product, rinse thoroughly before recycling
Special Precautions: Do not discharge into natural water bodies or sewer system in large quantities

Transport Information

UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as hazardous
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions for User: Protect packages from physical harm, moisture, and direct sunlight during transit

Regulatory Information

Safety, Health, Environmental Regulations: Not listed as hazardous under major chemical regulations
Inventory Status: Listed on major chemical inventories like TSCA (USA), EINECS (EU), DSL (Canada)
SARA Title III (USA): Not subject to reporting
REACH Regulation (EU): Pre-registered and compliant for substance category
OSHA Status: Non-hazardous
Other Labeling Requirements: As per local labeling regulations for non-hazardous laboratory chemicals