Adenosine Material Safety Data Sheet (MSDS)

Identification

Product Name: Adenosine
Chemical Formula: C10H13N5O4
CAS Number: 58-61-7
Synonyms: 6-Amino-9-beta-D-ribofuranosyl-9H-purine
Recommended Use: Biological research, pharmaceutical ingredient
Supplier: Refer to packaging label
Emergency Contact: Refer to local poison control center or medical facility

Hazard Identification

Classification: Not classified as hazardous under GHS.
Acute Health Effects: May cause respiratory or skin irritation in sensitive individuals. Dust exposure could irritate the eyes.
Chronic Health Effects: Long-term exposure is not well-studied, but possible respiratory issues may arise from repeated inhalation.
Label Elements: No specific hazard symbols required. Recommended to avoid unnecessary exposure.
Routes of Entry: Inhalation, ingestion, skin contact, eye contact
Signal Word: Not applicable
Precautionary Statements: Avoid dust formation and inhalation. Wash hands after handling.

Composition / Information on Ingredients

Chemical Name: Adenosine
Concentration: ≥98%
Impurities: Typically trace amounts of related purine compounds
Molecular Weight: 267.24 g/mol
Structure: Purine ribonucleoside, white crystalline powder

First Aid Measures

Inhalation: Move to fresh air, seek medical attention for respiratory symptoms.
Skin Contact: Rinse affected area with water and soap for at least 15 minutes. Remove contaminated clothing.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present. Seek medical care if irritation persists.
Ingestion: Rinse mouth with water, never induce vomiting unless instructed by a medical professional. Seek immediate medical attention if discomfort develops.
Symptoms and Effects: Potential for mild irritation to exposed tissues; significant overexposure unlikely outside of industrial settings.

Fire-Fighting Measures

Suitable Extinguishing Media: Use carbon dioxide, dry chemical, or foam. Avoid water streams if possible to prevent spread of material.
Unsuitable Extinguishing Media: Water may be ineffective for large fires.
Hazards: Combustion yields carbon oxides, nitrogen oxides, and potentially toxic fumes.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Specific Hazards: Dust can form explosive mixtures with air if concentrations are high.

Accidental Release Measures

Personal Precautions: Wear protective clothing, gloves, goggles, and mask to prevent contact with dust.
Environmental Precautions: Prevent material from entering soil, sewers, or waterways.
Methods for Cleaning Up: Sweep up dry spillages, avoid creating airborne dust, collect in suitable container for disposal. Ventilate area and wash site after material pick-up.

Handling and Storage

Handling: Wear appropriate protective gear during handling, use engineering controls to reduce airborne particles, wash hands thoroughly after use, avoid breathing dust, and do not eat or drink while handling.
Storage: Store in a cool, dry, well-ventilated place, keep container tightly sealed, protect from light and moisture, separate from food and incompatible materials, label containers clearly, secure from unauthorized access.

Exposure Controls and Personal Protection

Engineering Controls: Use fume hood or local ventilation to limit airborne concentrations.
Personal Protective Equipment: Use gloves (nitrile recommended), chemical-resistant goggles, lab coats, and adequate respiratory protection if dust forms.
Occupational Exposure Limits: No established limits, but minimize exposure.
Hygiene Measures: Wash hands and face after handling, do not touch face or eyes, prevent contamination of clothing, separate work clothing from home use, regular monitoring for surface contamination.

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 234-236°C
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in water, slightly soluble in ethanol
pH: 5.0 – 7.0 (1% aqueous solution)
Vapor Pressure: Not available
Density: Approximately 2.08 g/cm³
Flash Point: Not available
Partition Coefficient (log Kow): -1.2

Stability and Reactivity

Chemical Stability: Stable under recommended storage and normal conditions.
Incompatible Materials: Strong oxidizing agents, strong acids, bases.
Polymersation: No hazardous polymerization.
Decomposition: Yields carbon oxides and nitrogen compounds on combustion.
Conditions to Avoid: Excessive heat, moisture, exposure to air and light may degrade the product.

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Acute Toxicity: LD50 (oral, rat) > 2000 mg/kg, suggesting low systemic toxicity in small quantities.
Chronic Toxicity: No established data of chronic effects or carcinogenicity.
Irritation: May cause mild skin, eye, and respiratory tract irritation.
Other Effects: Not classified as mutagenic or teratogenic, but research substances demand respect for unknown risks.
Sensitization: No known sensitizing effects.

Ecological Information

Aquatic Toxicity: Low bioaccumulation potential, likely minimal acute aquatic toxicity.
Mobility in Soil: Highly soluble in water, can disperse in aquatic systems if released.
Degradation: Readily biodegradable under environmental conditions.
Persistence: No evidence for persistence or bioaccumulation.
Other Ecological Effects: Limited data exist, prudent to prevent significant release due to unknown long-term impacts.

Disposal Considerations

Methods of Disposal: Incinerate in accordance with local, regional, or national regulations for laboratory waste. Do not dispose into environment or regular trash.
Container Disposal: Triple rinse, puncture, and dispose as chemical waste.
Precautions: Anyone handling waste should wear protective equipment and verify absence of residues in containers before discarding.

Transport Information

UN Number: Not regulated for transport.
Proper Shipping Name: Not classified as dangerous goods.
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Prevent container damage and spillage, avoid conditions that could produce dust during handling or transport, secure packaging against physical damage.

Regulatory Information

OSHA: Not classified as hazardous under OSHA regulations.
TSCA (USA): Listed on the TSCA Inventory.
EU Regulation: Not classified for hazard under REACH regulation.
Canada DSL/NDSL: Listed/Exempt
Other International Inventory: Status can vary, check country-specific regulations.
Special Notes: Handle in accordance with good laboratory practice and local regulations.
Labeling Requirements: Use standard laboratory precautionary labeling, section access where chemical is handled.